反应详情

温度

110 °C

To the solution of 2-(4-{[4-(trifluoromethyl)phenyl]oxy}phenyl)ethyl imidocarbamate (50 mg, 0.114 mmol) and methyl 2-formyl-3-(1-methyl-1H-pyrazol-4-yl)propanoate (27 mg, 0.138 mmol) in NMP (1 mL), was added K2CO3 (60 mg, 0.434 mmol). The mixture was heated with a microwave reactor at 110° C. for 1 h. Purification via MDAP then afforded the title compound (6.8 mg, 10.19% yield). LCMS: rt=3.30 min, [M+H+]=471

1. customPurification via MDAP