反应详情

温度

115 °C

To the solution of 2-{4-[(3-fluoro-4-methylphenyl)oxy]phenyl}ethyl imidocarbamate (100 mg, 0.249 mmol) and methyl 2-formyl-3-(5-pyrimidinyl)propanoate (58 mg, 0.299 mmol) in NMP (2 mL) was added K2CO3 (138 mg, 0.997 mmol). The mixture was heated with a microwave reactor at 115° C. for 2 h. Purification via MDAP then afforded the title compound (4 mg, 3.71% yield). LCMS: rt=3.19 min, [M+H+]=433

1. customPurification via MDAP