N-methyl-2-pyrrolidone → 1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazole-4-carbonitrile

HRID 475189Notes

Reaction equation

Br[C:2]1[C:10]2[N:9]=[CH:8][N:7]([CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][O:12]3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:17][N:18]1C(=O)CCC1>[C-]#N.[C-]#N.[Zn+2].C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[O:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH:11]1[N:7]1[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:17]#[N:18])[C:10]=2[N:9]=[CH:8]1

Participants

Conditions

Temperature: 85 °C

Procedure

A mixture of 54 (1.30 g, 4.62 mmol), Zn(CN)2 (1.08 g, 9.24 mmol), Pd(PPh3)4 (0.53 g, 0.46 mmol) and NMP (15 mL) was stirred under nitrogen at 85° C. for 14 h. The mixture was filtered and the filtrate was purified by reverse phase chromatography eluting with 35% MeCN/H2O (containing 0.5% ammonia) to afford 0.75 g (70%) 1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazole-4-carbonitrile (56) as brown solid: MS (ESI) m/z=228.3 [M+l]+.

Workup

filtrationThe mixture was filtered
customthe filtrate was purified by reverse phase chromatography
washeluting with 35% MeCN/H2O (containing 0.5% ammonia)

Sources & evidence

ORD record: ord-a65700297554431ea60b8238bbb984d6
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08637537B2

Reaction notes

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