反应详情

1-[1-(1-Methoxycarbonylpiperidin -4-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one (32 mg) was dissolved in 5 ml of chloroform and 9 mg of acetyl chloride and 11 mg of triethylamine were added to the solution, followed by one day's stirring at room temperature. Saturated aqueous sodium bicarbonate solution was added to the reaction liquid and extracted with chloroform. The extract was dried over anhydrous sodium sulfate, concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol=20/1) to provide 5.1 mg of the title compound as a colorless oil.

1. extractionextracted with chloroform
2. dry with materialThe extract was dried over anhydrous sodium sulfate
3. concentrationconcentrated
4. customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol=20/1)