反应详情

A mixture of 108 (170 mg, 0.38 mmol) and TsOH.H2O (72 mg, 0.38 mmol) in MeOH (5 mL) and water (1 mL) was heated at reflux for 2 h. After solvent was removed in vacuo, the residue was purified by preparative HPLC to give 60 mg (43%) of I-28 as white solid.

1. temperaturewas heated
2. temperatureat reflux for 2 h
3. customAfter solvent was removed in vacuo
4. customthe residue was purified by preparative HPLC
5. customto give 60 mg (43%) of I-28 as white solid