反应详情

温度

120 °C

A tube was charged with 53 (350 mg, 1.47 mmol), 199 (340 mg, 1.47 mmol), and DIPEA (5 mL) in IPA (10 mL), degassed, sealed and heated at 120° C. for 48 h. The solvent was evaporated in vacuo. The crude product was purified by SiO2 chromatography to afford 600 mg (94%) of N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-((1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methyl)pyrimidine-2,4-diamine (200) as yellow solid: MS (ESI) m/z=431.2 [M+1]+.

1. customdegassed
2. customsealed
3. customThe solvent was evaporated in vacuo
4. customThe crude product was purified by SiO2 chromatography