Diisopropylethylamine → HCID 71529020, compound

HRID 475275Notes

Reaction equation

HRID 475275 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[NH:13][N:12]=[C:11]([CH:14]3[CH2:16][CH2:15]3)[CH:10]=2)[CH:5]=[CH:4][N:3]=1.[Cl:17][C:18]1[CH:26]=[C:25]2[C:21]([CH:22]=[CH:23][NH:24]2)=[CH:20][C:19]=1[CH2:27][NH2:28].CCN(C(C)C)C(C)C>CC(O)C>[Cl:17][C:18]1[CH:26]=[C:25]2[C:21]([CH:22]=[CH:23][NH:24]2)=[CH:20][C:19]=1[CH2:27][NH:28][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:10]=[C:11]([CH:14]3[CH2:16][CH2:15]3)[NH:12][N:13]=2)[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 82408684HCID 82408684, compoundHCID 178478345HCID 178478345, compound

Product 1

HCID 71529020HCID 71529020, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
120 °C

Procedure

A sealed vial was charged with 53 (80 mg, 0.34 mmol), 244 (45 mg, 0.25 mmol), DIPEA (100 mg, 0.75 mmol), and IPA (3.0 mL). The reaction mixture was heated at 120° C. for 18 h. The solution was concentrated and purified by preparative HPLC to afford 40 mg (42%) of I-93 as white solid.

Workup

  1. concentrationThe solution was concentrated
  2. custompurified by preparative HPLC
  3. customto afford 40 mg (42%) of I-93 as white solid

Sources & evidence

ORD record
ord-10c74a0ba81f4fbf9f8c9a5aa8c47aa4
Source dataset
uspto-grants-2014_01
Patent number
US08637537B2

Reaction notes

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