Urea → HCID 178517174, compound

HRID 475329Notes

Reaction equation

HRID 475329 reaction equation
[NH2:1][C:2]1[C:3]([CH:9]=O)=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[NH2:11][C:12](N)=[O:13]>O>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[C:3]([N:4]=1)=[CH:9][NH:11][C:12](=[O:13])[N:1]=2

Participants

4

Reactant 2

HCID 1176UreaHCID 574611393-Amino-6-chloropyridine-2-carbaldehyde

Product 1

HCID 178517174HCID 178517174, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
180 °C

Procedure

3-amino-6-chloro-pyridine-2-carbaldehyde (3.2 g, 13.0 mmol) is mixed thoroughly with urea (7.8 g, 130 mmol) and heated to 180° C. in the preheated oil bath for 3 h. Then the reaction mixture is suspended in H2O, the precipitate is filtered off and 6-chloro-3H-pyrido[3,2-d]pyrimidin-2-one is obtained.

Workup

  1. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-807bfca2af4c47ee97433cf8fbcbe68d
Source dataset
uspto-grants-2014_01
Patent number
US08637549B2

Reaction notes

Loading…