Trifluoroacetic acid → HCID 23135151, compound

HRID 475514Notes

Reaction equation

HRID 475514 reaction equation
C([O:5][C:6]([C:8]1[C:12]2[CH2:13][C:14]([O:16]CC)=[CH:15][C:11]=2[N:10]([S:19]([C:22]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=2)(=[O:21])=[O:20])[N:9]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[O:16]=[C:14]1[CH2:13][C:12]2[C:8]([C:6]([OH:7])=[O:5])=[N:9][N:10]([S:19]([C:22]3[CH:23]=[CH:24][C:25]([CH3:28])=[CH:26][CH:27]=3)(=[O:21])=[O:20])[C:11]=2[CH2:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58713644HCID 58713644, compound

Product 1

HCID 23135151HCID 23135151, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the intermediate from step B above, (414 mg, 1.02 mmol) in CH2Cl2 (2 mL) was added trifluoroacetic acid (2 mL). After stirring the reaction at room temperature for 1.5 hours it was concentrated in vacuo and azeotroped with toluene (2×). This material was used in the next step without any further purification.

Workup

  1. customthe reaction at room temperature for 1.5 hours it
  2. concentrationwas concentrated in vacuo
  3. customazeotroped with toluene (2×)
  4. customThis material was used in the next step without any further purification

Sources & evidence

ORD record
ord-5583649740ad4ac79bcc6d206c7581a2
Source dataset
uspto-grants-2014_01
Patent number
US08637555B2

Reaction notes

Loading…