HCID 58075657, compound → HCID 58075835, compound

HRID 475857Notes

Reaction equation

HRID 475857 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH3:13])[C:9]2[CH:8]=[CH:7][CH2:6][C:5]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)([OH:14])[C:4]=2[N:3]=1>CCOC(C)=O.[Pd]>[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH3:13])[C:9]2[CH2:8][CH2:7][CH2:6][C:5]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)([OH:14])[C:4]=2[N:3]=1

Participants

4

Reactant 1

HCID 58075657HCID 58075657, compound

Product 1

HCID 58075835HCID 58075835, compoundYield 99.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 2-chloro-4-(methylamino)-8-phenyl-7,8-dihydroquinazolin-8-ol (20 mg) in EtOAc (5 mL) was added 5% Pd/C (6 mg), and the resulting suspension was stirred under a hydrogen balloon for 1 h. The reaction mixture was filtered through a pad of Celite to give the title compound as a colorless oil (20 mg).

Workup

  1. filtrationThe reaction mixture was filtered through a pad of Celite

Sources & evidence

ORD record
ord-7ab19487b56146cdb7433819e533e11b
Source dataset
uspto-grants-2014_01
Patent number
US08637525B2

Reaction notes

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