反应详情

温度

80 °C

To a solution of 2-[2-(7-fluoro-4-propargyl-2H-1,4-benzoxazin-3(4H)-on-6-yl)hydrazino]cyclohexanone oxime (0.4 g) in tetrahydrofuran (6 ml), 15% aqueous pyridine (7 g) was added, and a solution of copper sulfate (0.7 g) in water (1.5 ml) was added thereto, followed by heating at 80° C. for 2 hours. The reaction mixture was allowed to cool, combined with water and extracted with ethyl acetate. The organic layer was washed with 10% aqueous copper sulfate solution, dried and concentrated. The residue was purified by silica gel column chromatography using ethyl acetate as an eluent to give Compound No. 1 (0.2 g). m.p., 186°-187° C.

1. temperatureto cool
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with 10% aqueous copper sulfate solution
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography
7. customto give Compound No
8. customm.p., 186°-187° C.