Sodium Sulfite → Sodium 3-trifluoromethylbenzylsulfonate

HRID 476517Notes

Reaction equation

HRID 476517 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]Cl.[S:13]([O-:16])([O-:15])=[O:14].[Na+:17].[Na+]>O>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][S:13]([O-:16])(=[O:15])=[O:14].[Na+:17]

Participants

4

Reactant 2

HCID 24437Sodium SulfiteHCID 697163-(Trifluoromethyl)benzyl chloride

Product 1

HCID 23700704Sodium 3-trifluoromethylbenzylsulfonateYield 90.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture containing 50 g of 3-trifluoromethylbenzyl chloride and 32.4 g of sodium sulfite in 200 ml of water was refluxed for five hours and then concentrated by evaporation. The concentrate was then filtered to collect the precipitate (product). The precipitate was then washed with ethyl ether and then dried in a vacuum oven affording 61 g of sodium 3-trifluoromethylbenzylsulfonate.

Workup

  1. temperaturewas refluxed for five hours
  2. concentrationconcentrated by evaporation
  3. filtrationThe concentrate was then filtered
  4. customto collect the precipitate (product)
  5. washThe precipitate was then washed with ethyl ether
  6. customdried in a vacuum oven

Sources & evidence

ORD record
ord-3035ba2ef0a1410d9769ed450dd25250
Source dataset
uspto-grants-1989_12
Patent number
US04885027

Reaction notes

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