反应详情

To 100 ml of tetrahydrofuran, 1.3 g of ethanethiol and 1.5 g of potassium carbonate and then 4.4 g of methyl 3-bromomethyl-2-chloro-4-methanesulfonylbenzoate were added, and the mixture was stirred for 1 day at room temperature. Then, the mixture was stirred further for 1 hour at a temperature of from 50° to 60° C. After cooling, chloroform was added thereto, and the mixture was washed with a dilute potassium carbonate aqueous solution. The chloroform layer was separated and dried. Then, the solvent was distilled off to obtain 4.1 g of methyl 2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoate as an oily substance.

1. stirringThen, the mixture was stirred further for 1 hour at a temperature of from 50° to 60° C
2. temperatureAfter cooling
3. washthe mixture was washed with a dilute potassium carbonate aqueous solution
4. customThe chloroform layer was separated
5. customdried
6. distillationThen, the solvent was distilled off