Water → HCID 14324491, compound

HRID 476838Notes

Reaction equation

HRID 476838 reaction equation
[C:1]([CH2:7][C:8]([O:10]CC)=O)(=O)[C:2]([CH3:5])([CH3:4])[CH3:3].O.[NH2:14][NH2:15].O>C(O)C>[C:2]([CH:1]1[CH2:7][C:8](=[O:10])[NH:15][NH:14]1)([CH3:5])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 962Water2×HCID 24654Hydrazine hydrate (1:1)HCID 86950Ethyl pivaloylacetate

Product 1

HCID 14324491HCID 14324491, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.0 kg of ethyl pivaloylacetate was dissolved in 1.0 liter of ethanol, and 320 g of hydrazine hydrate was dropwise added thereto while cooled with water. After completion of the addition, the reaction was carried out overnight at room temperature, and then 5.0 liter of water was added thereto and stirred. The crystal as precipitated was filtered out under reduced pressure and fully washed with water, and then this was further washed with a little amount of methanol and dried with air. Yield: 812 g.

Workup

  1. additionAfter completion of the addition
  2. customThe crystal as precipitated
  3. filtrationwas filtered out under reduced pressure
  4. washfully washed with water
  5. washthis was further washed with a little amount of methanol
  6. customdried with air

Sources & evidence

ORD record
ord-5df4c011a973478fb71c25127529c43d
Source dataset
uspto-grants-1989_12
Patent number
US04886736

Reaction notes

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