Methylamine → HCID 19836622, compound

HRID 476846Notes

Reaction equation

HRID 476846 reaction equation
[CH3:1][C:2]1([CH3:13])[CH2:4][N:3]1[P:5](Br)([N:7]1[CH2:9][C:8]1([CH3:11])[CH3:10])=[S:6].[CH3:14][NH2:15]>C1COCC1>[CH3:1][C:2]1([CH3:13])[CH2:4][N:3]1[P:5]([N:7]1[CH2:9][C:8]1([CH3:11])[CH3:10])(=[S:6])[NH:15][CH3:14]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 54098565HCID 54098565, compound

Product 1

HCID 19836622HCID 19836622, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a similar manner 0.025 moles of P,P-bis(2,2-dimethyl-1-aziridinyl)thiophosphinic bromide in about 170 milliliters of THF, prepared in accordance with Example 1, is saturated with an excess of gaseous methylamine, kept overnight at 4° C., filtered, concentrated on a rotary evaporator at room temperature, and vacuum distilled to provide about 65% yield of P,P-bis(2,2-dimethyl-1-aziridinyl)-N methylthiophosphinic amide.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated on a rotary evaporator at room temperature
  3. distillationvacuum distilled

Sources & evidence

ORD record
ord-213cc3ff20f0414b9f45dcbb8e927f15
Source dataset
uspto-grants-1989_12
Patent number
US04886790

Reaction notes

Loading…