反应详情

温度

0 °C

To a suspension of 4 g of benzyltriphenylphosphonium chloride in 20 ml of tetrahydrofuran was added 7.07 ml of 1.6M hexane solution of n-butyl lithium under cooling at 0° C. After stirring at room temperature for 30 minutes, 1 g of 2-hydroxytetrahydrofuran was added, followed by stirring at room temperature for 16 hours. Subsequently, after refluxing for 2 hours, insolubles were filtered off and the solvent was distilled off. The residue was purified by silica gel column chromatography (solvent: hexane-ethyl acetate=2:1) to give 2 g of (E)-5-phenyl-4-penten-1-ol as a colorless oily substance.

1. stirringby stirring at room temperature for 16 hours
2. temperatureSubsequently, after refluxing for 2 hours
3. filtrationinsolubles were filtered off
4. distillationthe solvent was distilled off
5. customThe residue was purified by silica gel column chromatography (solvent: hexane-ethyl acetate=2:1)