HCID 1516513, compound → HCID 70395373, compound

HRID 477025Notes

Reaction equation

HRID 477025 reaction equation
[NH2:1][C:2]1[C:11]([F:12])=[C:10](F)[C:9]([F:14])=[C:8]2[C:3]=1[C:4](=[O:21])[C:5]([C:18]([OH:20])=[O:19])=[CH:6][N:7]2[CH:15]1[CH2:17][CH2:16]1.[NH2:22][CH2:23][C@H:24]1[C@H:28]([CH3:29])[CH2:27][NH:26][CH2:25]1>CN(C)C=O>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([N:26]2[CH2:27][C@@H:28]([CH3:29])[C@H:24]([CH2:23][NH2:22])[CH2:25]2)[C:9]([F:14])=[C:8]2[C:3]=1[C:4](=[O:21])[C:5]([C:18]([OH:20])=[O:19])=[CH:6][N:7]2[CH:15]1[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 1516513HCID 1516513, compoundHCID 139109475-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 70395373HCID 70395373, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the same manner as described in Example 16 (1), a mixture of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, trans-3-aminomethyl-4-methylpyrrolidine, and dimethylformamide was stirred at room temperature for 24 hours to give 5-amino-7-(trans-3-aminomethyl-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro4-oxoquinoline-3-carboxylic acid, which was recrystallized from ethanol, m.p. 223°-225° C.

Sources & evidence

ORD record
ord-4eb8072f920d44298fc949a48ec915b8
Source dataset
uspto-grants-1989_12
Patent number
US04886810

Reaction notes

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