Hydrochloric Acid → (2R)-2-amino-3-(3-carboxyphenyl)-1-propanol hydrochloride
Reaction equation
[OH:1][CH2:2][C@H:3]([NH:14]C(=O)C)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([OH:13])=[O:12])[CH:6]=1.[ClH:18]>>[ClH:18].[NH2:14][C@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([OH:13])=[O:12])[CH:6]=1)[CH2:2][OH:1]Participants
3
Conditions
- Temperature
- 100 °C
Procedure
The process is performed as in Example 2, starting with 1.96 g of N-[(1R)-2-hydroxy-1-(3-carboxybenzyl)ethyl]acetamide in 14 cm3 of aqueous 6N hydrochloric acid heated at a temperature in the region of 100° C. for 17 hours. After an identical work-up, 2.16 g of (2R)-2-amino-3-(3-carboxyphenyl)-1-propanol hydrochloride are obtained in the form of a white solid melting at 194° C.
Sources & evidence
- ORD record
- ord-b206d38bc336441e843339c043259704
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06699895B2
Reaction notes
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