HCID 19835546, compound → HCID 19835519, compound

HRID 477379Notes

Reaction equation

HRID 477379 reaction equation
C([NH:4][C:5]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:6]=1[O:7][CH2:8][CH:9]([OH:18])[CH2:10][N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C:12]1=[O:17])(=O)C>Cl>[NH2:4][C:5]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:6]=1[O:7][CH2:8][CH:9]([OH:18])[CH2:10][N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C:12]1=[O:17]

Participants

3

Reactant 1

HCID 19835546HCID 19835546, compound

Product 1

HCID 19835519HCID 19835519, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2 g (0.0057 mol) of the 1-(2'-acetylamino-4'-nitrophenoxy)-3-succinimidopropan-2-ol obtained in the second step are heated for one hour, in a boiling water-bath, in 10 ml of hydrochloric acid (specific gravity=1.18), with stirring. After the reaction medium has been cooled, diluted and rendered alkaline, the expected product precipitates. It is filtered off, washed with water and recrystallised from ethanol. It melts at 200° C.

Workup

  1. temperatureAfter the reaction medium has been cooled
  2. additiondiluted
  3. customthe expected product precipitates
  4. filtrationIt is filtered off
  5. washwashed with water
  6. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-0a8b9639e2324fd68adcb12d1572e2ff
Source dataset
uspto-grants-1989_12
Patent number
US04888025

Reaction notes

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