反应详情

A mixture of 59.45 g of hexadecylamine, 10.60 g of gamma butyrolactone, 200 ml of toluene, and 20 mg of zinc chloride was refluxed under nitrogen for three days. Upon cooling, the reaction mixture formed a precipitate which was recrystallized twice from toluene to yield 321.5 g (78.12%) of N-hexadecyl-4-hydroxybutyramide, m.p. 89.5°-90°

1. temperaturewas refluxed under nitrogen for three days
2. temperatureUpon cooling
3. customthe reaction mixture formed a precipitate which
4. customwas recrystallized twice from toluene