Bromine → HCID 14122312, compound

HRID 477583Notes

Reaction equation

HRID 477583 reaction equation
BrBr.[Cl:3][C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[CH:13]([C:17]#[N:18])[C:14]([NH2:16])=[S:15].C(=O)([O-])O.[Na+]>C(Cl)Cl>[NH2:16][C:14]1[S:15][C:6]2[CH:7]=[C:8]([N+:10]([O-:12])=[O:11])[CH:9]=[C:4]([Cl:3])[C:5]=2[C:13]=1[C:17]#[N:18]

Participants

5

Reactant 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 14122316HCID 14122316, compound

Product 1

HCID 14122312HCID 14122312, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 9.2 ml (0.18 mol) of bromine in 72 ml of methylene chloride is added dropwise at room temperature to a suspension of 46 g of 2-chloro-4-nitrophenylcyanothioacetamide (0.18 mol) and 30 g of sodium hydrogencarbonate (0.36 mol) in 650 ml of methylene chloride. This was followed by 2 hours of stirring at room temperature, filtering off with suction and repeated washing of the yellow residue with water.

Workup

  1. filtrationfiltering off with suction
  2. washrepeated washing of the yellow residue with water

Sources & evidence

ORD record
ord-8d1b59cfd95a45899c2cf367c2ceac4b
Source dataset
uspto-grants-1989_12
Patent number
US04888432

Reaction notes

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