Hydrochloric Acid → HCID 19913674, compound

HRID 477803Notes

Reaction equation

HRID 477803 reaction equation
[CH2:1]([N:3]([CH2:28][CH2:29][O:30][CH3:31])[C:4]([C:6]1[CH:7]=[C:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:9](=[O:21])[N:10]2[N:19]=[CH:18][C:17]3[C:12](=[CH:13][C:14]([Cl:20])=[CH:15][CH:16]=3)[C:11]=12)=[O:5])[CH3:2].Cl.C(OCC)(=O)C>CO>[CH2:1]([N:3]([CH2:28][CH2:29][O:30][CH3:31])[C:4]([C:6]1[CH:7]=[C:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:9](=[O:21])[N:10]2[NH:19][CH2:18][C:17]3[C:12](=[CH:13][C:14]([Cl:20])=[CH:15][CH:16]=3)[C:11]=12)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 19898595HCID 19898595, compound

Product 1

HCID 19913674HCID 19913674, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

from N-ethyl-10-chloro-N-(2-methoxyethyl)-4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazine-1-carboxamide in methanol/glacial acetic acid (10:1), but without the addition of saturated methanolic hydrochloric acid, there is obtained N-ethyl-10-chloro-6,7-dihydro-N-(2-methoxyethyl)-4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazine-1-carboxamide of m.p. 184°-185° (ethyl acetate);

Sources & evidence

ORD record
ord-91627e3fce234c86bfde791905848995
Source dataset
uspto-grants-1989_12
Patent number
US04889854

Reaction notes

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