Hydrochloric Acid → HCID 19872550, compound

HRID 477890Notes

Reaction equation

HRID 477890 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[N:12]([CH3:15])[C:11]3[CH:16]=[C:17]([NH:20][C:21](=O)CC)[CH:18]=[CH:19][C:10]=3[S:9]2(=[O:26])=[O:25])=[CH:4][CH:3]=1.Cl.C([O-])(O)=O.[Na+]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[N:12]([CH3:15])[C:11]3[CH:16]=[C:17]([NH:20][CH3:21])[CH:18]=[CH:19][C:10]=3[S:9]2(=[O:25])=[O:26])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 70394957HCID 70394957, compound

Product 1

HCID 19872550HCID 19872550, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-(4-chlorophenyl)-4-methyl-6-(N-methylacetylamino)-2H-1,2,4-benzothiadiazine-3(4H)-one 1,1-dioxide (0.14 g) in ethanol (2.8 ml) was added conc. hydrochloric acid (2.8 ml). The mixture was refluxed for one hour and neutralized with aqueous saturated NaHCO3 solution. The resulting crystals were collected by filtration to give 2-(4-chlorophenyl)-4-methyl-6-(N-methylamino)-2H-1,2,4-benzothiadiazine-3(4H)-one 1,1-dioxide (0.105 g) as colorless powder.

Workup

  1. filtrationThe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-a2fa5a29f0434e3f9fac6238a14c2f83
Source dataset
uspto-grants-1989_12
Patent number
US04889851

Reaction notes

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