反应详情

A solution of 2-ethoxy-3-{4-[2-(heptyl-p-tolylacetyl-amino)-ethyl]-phenyl}-propionic acid methyl ester (21 mg, 0.044 mmol) and 1 M LiOH (0.131 mmol, 0.131 mL) in tetrahydrofuran (1 mL) was allowed to stir at room temperature for 24 hours. 2 N HCL was then added until the solution had a pH<2. After dilution with twice its volume in water, the aqueous layer was extracted with diethyl ether (2×). The organic layers were combined, washed with 2 M HCl (2×), dried over anhydrous sodium sulfate, and concentrated to give 2-ethoxy-3-{4-[2-(heptyl-p-tolylacetyl-amino)-ethyl]-phenyl}-propionic acid as a clear oil (19.5 mg, 95%).

1. addition2 N HCL was then added until the solution
2. extractionAfter dilution with twice its volume in water, the aqueous layer was extracted with diethyl ether (2×)
3. washwashed with 2 M HCl (2×)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated