2-Chlorobenzyl chloride → 1-[(2-Chlorophenyl)methyl]piperidin-4-one

HRID 478491Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[Cl:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11]Cl>>[Cl:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11][N:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 119062-Chlorobenzyl chloride

HCID 337214-Piperidone

Product 1

HCID 119595311-[(2-Chlorophenyl)methyl]piperidin-4-one

Procedure

1-(2-Chlorobenzyl)-4-piperidone is prepared from 4-piperidone and 2-chlorobenzyl chloride essentially as described above in Example 38, Scheme C, step a.

Sources & evidence

ORD record: ord-f31bdd11fb7c48a7bb4d4421e73bc64f
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642231B2

Reaction notes

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