反应详情

温度

80 °C

4-(Piperazin-1-yl)-benzoic acid methyl ester (19 mmol), 2-bromoethylmethylether (21 mmol), and potassium carbonate (22.8 mmol) are suspended in acetonitrile (50 ml) and stirred at 80° C. for 8 hours. After evaporation of the solvent, the residue is dissolved in water and extracted three times with CH2Cl2. The extract is dried over sodium sulfate and evaporated. The residue is suspended in diethylether/pentane and the solid filtered of and dried (vacuum). A powder with mp. 103-105° C. is obtained.

1. customAfter evaporation of the solvent
2. dissolutionthe residue is dissolved in water
3. extractionextracted three times with CH2Cl2
4. dry with materialThe extract is dried over sodium sulfate
5. customevaporated
6. filtrationthe solid filtered of and
7. customdried (vacuum)
8. customA powder with mp. 103-105° C. is obtained