Triethyl phosphonoacetate → Ethyl isonicotinylacetate

HRID 478729Notes

Reaction equation

[CH:1](=O)[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.C(OP([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])(OCC)=O)C>>[N:5]1[CH:6]=[CH:7][C:2]([CH2:1][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:3][CH:4]=1

Participants

Reactant 2

HCID 13345Triethyl phosphonoacetate

HCID 133894-Pyridinecarboxaldehyde

Product 1

HCID 12229233Ethyl isonicotinylacetate

Procedure

The procedure of Synthetic Example 4 was repeated using isonicotinaldehyde and ethyl diethylphosphonoacetate to obtain ethyl 3-(pyridin-4-yl)propionate.

Sources & evidence

ORD record: ord-818c3ddabf1f436c8fa301eba4571d0e
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642250B2

Reaction notes

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