反应详情

Ethyl 2,6-dichloro-5-fluoronicotinate (1) (30.0 g) was dissolved in a mixture of 60 mL of trifluoro acetic acid and 60 mL of 7.5 N HCl. The mixture was refluxed with stirring for 26 h. It was cooled and the trifluoroacetic acid was removed under reduced pressure. The solution was mixed with 150 mL water, the resulting precipitate was filtered, washed with hexane and dried to yield 16.5 g of 2,6-dichloro-5-fluoro nicotinic acid (2). m.p.=152-156° C.

1. temperatureThe mixture was refluxed
2. temperatureIt was cooled
3. customthe trifluoroacetic acid was removed under reduced pressure
4. additionThe solution was mixed with 150 mL water
5. filtrationthe resulting precipitate was filtered
6. washwashed with hexane
7. customdried