反应详情

温度

50 °C

Compound 7 (1.4 g, 6.0 mmol) was added dropwise into a flask equipped with a H2 balloon and containing the mixture of Pd(OH)2 (400 mg, 20% on carbon) and HCl (1.15 mL, 35% in H2O, 19.5 mmol) in EtOH (50 mL). The mixture was stirred under H2 at 50° C. for 10 h. Solid was filtered out and washed with hot HOCH3 (2×10 mL). The combined liquid was evaporated to dryness to give HCl salt of (3R)-1-pyrrolidin-3-yl-piperidine 9 (1.4 g, 100%).

1. customequipped with a H2 balloon
2. additioncontaining
3. filtrationSolid was filtered out
4. washwashed with hot HOCH3 (2×10 mL)
5. customThe combined liquid was evaporated to dryness