反应详情

0.5 Gram of 2-(5-t-butyloxadiazol-3-yl)-3-chlorobenzoyl chloride was dissolved in 30 ml of tetrahydrofuran, and 0.3 g of 2-methyl-4-trifluoromethoxyaniline and 0.2 g of triethylamine were added thereto, the reaction was carried out for 1 hour under stirring. After completion of the reaction, the reaction mixture was poured into water, after extraction of the objective product with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate, the solvent was removed by distillation under reduced pressure, the residue thus obtained was purified by a silica gel column chromatography to obtain 0.22 g (yield: 29%) of the objective product.

1. customAfter completion of the reaction
2. extractionafter extraction of the objective product with ethyl acetate
3. dry with materialthe organic layer was dried over anhydrous sodium sulfate
4. customthe solvent was removed by distillation under reduced pressure
5. customthe residue thus obtained
6. customwas purified by a silica gel column chromatography