2-Nitropropane → HCID 21951129, compound

HRID 478973Notes

Reaction equation

HRID 478973 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[N+:5]([CH:8]([CH3:10])[CH3:9])([O-:7])=[O:6].[CH2:11]=O.[OH-].[Na+]>C(O)(C)C.O>[N+:5]([C:8]([CH3:11])([CH3:10])[CH2:9][NH:4][CH2:3][CH2:1][OH:2])([O-:7])=[O:6]

Participants

7

Reactant 4

HCID 3982-NitropropaneHCID 700EthanolamineHCID 712FormaldehydeHCID 14798Sodium Hydroxide

Product 1

HCID 21951129HCID 21951129, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

To a solution of 450 g (7.40 moles) of ethanolamine in 1000 ml of isopropanol, 607.8 g (6.55 moles) of 2-nitropropane and 100 ml of water are added. The solution is stirred at room temperature and 225.4 g (7.5 moles) of paraformaldehyde and 7 ml of 20% aqueous solution of sodium hydroxide (% w/v) are added, under stirring and maintaining the temperature at room temperature for 16 hours. The mixture is then heated to 50° C. being nitrogen bubbled into the mixture to eliminate the formaldehyde in excess. The mixture is then used for the reaction, without any isolation of the product.

Workup

  1. stirringunder stirring
  2. temperaturemaintaining the temperature at room temperature for 16 hours
  3. temperatureThe mixture is then heated to 50° C.
  4. custombubbled into the mixture
  5. customThe mixture is then used for the reaction, without any isolation of the product

Sources & evidence

ORD record
ord-217c5988cee3485e939f094e948ccfbc
Source dataset
uspto-grants-2003_11
Patent number
US06642383B2

Reaction notes

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