反应详情

6-Hydroxy-5-quinolinecarboxylic acid [as reported by Da Re, P. et al. in Ann. Chem. (Rome) 1970, 60(3), 215-24 (C.A. 73, 25338m)] is reacted with methanolic boron trifluoride solution for several hours. The resulting mixture is added to an aqueous solution of sodium bicarbonate to give finally a basic solution. The solution is extracted with chloroform. The chloroform extract is dried over anhydrous sodium sulfate and concentrated and the residue is crystallized from a suitable solvent.

1. customto give finally a basic solution
2. extractionThe solution is extracted with chloroform
3. extractionThe chloroform extract
4. dry with materialis dried over anhydrous sodium sulfate
5. concentrationconcentrated
6. customthe residue is crystallized from a suitable solvent