反应详情

1.1 g of 2,6-Dimethylphenol, 2.01 g of 2-(5-methyl-2-phenyl-oxazole-4yl)-ethanol 2.6 g of triphenylphosphin were dissolved in 30 ml THF and treated at 0° with 1.6 ml DEAD (Diethyl azodicarboxylate). The reaction mixture was kept overnight at RT. Water was added. Twofold extraction with AcOEt, washing with brine, drying over sodium sulfate, and evaporation of the solvents provided a crude product, which was purified by chromatography (SiO2; ether/cyclohexane) to yield 0.89 g of the title compound as a slightly yellow oil.

1. extractionTwofold extraction with AcOEt
2. washwashing with brine
3. dry with materialdrying over sodium sulfate, and evaporation of the solvents
4. customprovided a crude product, which
5. customwas purified by chromatography (SiO2; ether/cyclohexane)