反应详情

[rac]-2-Ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-indan-4-yl}-propionic acid ethyl ester (850 mg, 1.83 mmol ) was dissolved in 10 ml of dioxane; 5 ml of water and LiOH (4.58 ml of a 1N solution in water, 4.58 mmol) were then added slowly at room temperature. The resulting mixture was stirred overnight at room temperature and then poured onto ice, neutralized to pH 4 with HCl (1N) and extracted 3 times with AcOEt. The combined organic phases were washed with water, dried over magnesium sulfate and evaporated to give a colorless solid that was triturated in CH3CN for 15 minutes, filtered and dried to yield 470 mg (58.9%) of [rac]-2-ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-indan-4-yl}-propionic acid as colorless crystals.

1. additionpoured onto ice
2. extractionextracted 3 times with AcOEt
3. washThe combined organic phases were washed with water
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customto give a colorless solid
7. customthat was triturated in CH3CN for 15 minutes
8. filtrationfiltered
9. customdried