Hydrochloric Acid → HCID 18769996, compound

HRID 479301Notes

Reaction equation

HRID 479301 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[C:13]([CH:14]2[O:18][N:17]=[C:16]([CH3:19])[CH2:15]2)=[C:12]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7].O.Cl.[CH3:26]O>O1CCCC1>[CH3:26][C:11]1[C:12]([S:20]([CH3:23])(=[O:22])=[O:21])=[C:13]([CH:14]2[O:18][N:17]=[C:16]([CH3:19])[CH2:15]2)[C:4]([Cl:3])=[C:5]([CH:10]=1)[C:6]([OH:8])=[O:7]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 18770002HCID 18770002, compound

Product 1

HCID 18769996HCID 18769996, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

69.4 g (174 mmol) of 10% strength sodium hydroxide solution were added to a solution of 38.4 g (116 mmol) of methyl 2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoate in 400 ml of methanol and 400 ml of tetrahydrofuran. The mixture was stirred for 12 hours at room temperature, the solvent volume was reduced to half, and the mixture was poured into 1 1 of water. The pH was brought to 1 using 10% strength hydrochloric acid, and the precipitate which formed was filtered off with suction.

Workup

  1. customthe precipitate which formed
  2. filtrationwas filtered off with suction

Sources & evidence

ORD record
ord-970037bc15414e61976602e11cf89a58
Source dataset
uspto-grants-2003_11
Patent number
US06645919B1

Reaction notes

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