Hydrochloric Acid → HCID 18770438, compound

HRID 479383Notes

Reaction equation

HRID 479383 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH:16]([CH2:21][CH:22]2[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]2)[C:17]([O:19][CH3:20])=[O:18])[CH2:11][CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[ClH:1].[NH:9]1[CH2:10][CH2:11][CH:12]([CH2:15][CH:16]([CH2:21][CH:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2)[C:17]([O:19][CH3:20])=[O:18])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770408HCID 18770408, compound

Product 1

HCID 18770438HCID 18770438, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A 4N hydrogen chloride in ethyl acetate (1.0 ml; 4.0 mmol) was added to a solution in ethyl acetate (0.5 ml) of methyl 2,2-bis[(1-tert-butoxycarbonyl-4-piperidinyl)-methyl]acetate (210 mg; 0.45 mmol) synthesized by the above process, and the mixture was stirred at room temperature for 30 minutes and then concentrated under reduced pressure. The concentrated residue was suspended in diethyl ether and collected by filtration to obtain 116 mg (yield: 76%) of the title compound as a colorless crystalline powder (melting point: 269-271° C.).

Workup

  1. customsynthesized by the above process
  2. concentrationconcentrated under reduced pressure
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-29a4c5f6365a4fd8b08d7d6108d04008
Source dataset
uspto-grants-2003_11
Patent number
US06645957B2

Reaction notes

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