Hydrochloric Acid → HCID 18770450, compound

HRID 479417Notes

Reaction equation

HRID 479417 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:58]=[CH:57][C:17]([C:18]([N:20]3[CH2:26][CH2:25][CH2:24][N:23]([CH2:27][CH2:28][CH2:29][N:30]4[CH2:36][CH2:35][CH2:34][N:33]([C:37](=[O:56])[C:38]5[CH:43]=[CH:42][C:41]([C:44]6[CH:49]=[C:48]([O:50][CH3:51])[C:47]([O:52][CH3:53])=[C:46]([O:54][CH3:55])[CH:45]=6)=[CH:40][CH:39]=5)[CH2:32][CH2:31]4)[CH2:22][CH2:21]3)=[O:19])=[CH:16][CH:15]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[ClH:1].[CH3:51][O:50][C:48]1[CH:49]=[C:44]([C:41]2[CH:42]=[CH:43][C:38]([C:37]([N:33]3[CH2:34][CH2:35][CH2:36][N:30]([CH2:29][CH2:28][CH2:27][N:23]4[CH2:24][CH2:25][CH2:26][N:20]([C:18](=[O:19])[C:17]5[CH:57]=[CH:58][C:14]([C:6]6[CH:5]=[C:4]([O:3][CH3:2])[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=6)=[CH:15][CH:16]=5)[CH2:21][CH2:22]4)[CH2:31][CH2:32]3)=[O:56])=[CH:39][CH:40]=2)[CH:45]=[C:46]([O:54][CH3:55])[C:47]=1[O:52][CH3:53]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770401HCID 18770401, compound

Product 1

HCID 18770450HCID 18770450, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.025 ml; 0.30 mmol) was added to a solution of 1,1′-trimethylenedi[4-[4-(3,4,5-trimethoxyphenyl)benzoyl]hexahydro-l,4-diazepine] (46 mg; 0.060 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. The concentrated residue was suspended in diethyl ether and collected by filtration to obtain the title compound as a colorless crystalline powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-5358c49f3f9b4bc0ab45864a7614502f
Source dataset
uspto-grants-2003_11
Patent number
US06645957B2

Reaction notes

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