Hydrochloric Acid → 4-(4-Chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-(3-(2-methylphenoxy)propyl)oxazole hydrochloride

HRID 47942Notes

Reaction equation

HRID 47942 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([N:24]3[CH:28]=[CH:27][N:26]=[C:25]3[CH3:29])[O:11][C:12]=2[CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])=[CH:4][CH:3]=1.Cl>CC(C)=O>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([N:24]3[CH:28]=[CH:27][N:26]=[C:25]3[CH3:29])[O:11][C:12]=2[CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 98876724-(4-Chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole

Product 1

HCID 234318104-(4-Chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-(3-(2-methylphenoxy)propyl)oxazole hydrochloride

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a mixture of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-(3-(2-methylphenoxy)propyl)oxazole (1.0 g) and acetone (10 ml) was added conc. hydrochloric acid (0.3 ml) and the mixture was stood at room temperature. The precipitated crystals were collected by filtration (0.97 g). Recrystallization from ethanol gave the title compound.

Workup

  1. customwas stood at room temperature
  2. filtrationThe precipitated crystals were collected by filtration (0.97 g)
  3. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-6af87043127949da8464a34377af4e45
Source dataset
uspto-grants-2004_03
Patent number
US06699995B1

Reaction notes

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