Hydrochloric Acid → HCID 69493308, compound

HRID 479425Notes

Reaction equation

HRID 479425 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH:16]([CH2:31][N:32]([CH3:34])[CH3:33])[CH2:17][CH:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[CH2:11][CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[ClH:1].[ClH:1].[NH:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH:16]([CH2:31][N:32]([CH3:34])[CH3:33])[CH2:17][CH:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770440HCID 18770440, compound

Product 1

HCID 69493308HCID 69493308, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A 4N hydrogen chloride in ethyl acetate (1 ml; 4 mmol) was added to a solution in ethyl acetate (0.5 ml) of 1,3-bis(1-tert-butoxycarbonyl-4-piperidinyl)-2-[(dimethylamino)methyl]propane (67 mg; 0.14 mmol) synthesized by the process described in Referential Example 5, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure to obtain crude crystals of 1,3-bis(4-piperidinyl)-2-[(dimethylamino)methyl]propane trihydrochoride.

Workup

  1. customsynthesized by the process
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-29069ad0ae8346de9220527a09122a51
Source dataset
uspto-grants-2003_11
Patent number
US06645957B2

Reaction notes

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