Hydrochloric Acid → HCID 178478792, compound

HRID 479542Notes

Reaction equation

HRID 479542 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[N:8]#[C:9][NH2:10].[ClH:11]>>[ClH:11].[ClH:11].[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:9]([NH2:10])=[NH:8])[CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 9864CyanamideHCID 100093-Aminopyridine

Product 1

HCID 178478792HCID 178478792, compound

Procedure

3-Aminopyridine (38.96 g, 413.96 mmol) and cyanamide (21.40 g, 509.2 mmol) in 12N hydrochloric acid (271 mL) were stirred at 140-150° C. for 4 hours. Concentration under reduced pressure provided a heavy syrup which was purified by recrystalization from 1:1 isopropanol:diethyl ether (500 mL) to provide 60.2 g of the desired product as a white solid.

Workup

  1. concentrationConcentration under reduced pressure
  2. customprovided a heavy syrup which
  3. customwas purified by recrystalization from 1:1 isopropanol

Sources & evidence

ORD record
ord-d173fb80c51e4156a6baadf50c5ad9da
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Reaction notes

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