Nicotinamide → N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]nicotinamide

HRID 479562Notes

Reaction equation

HRID 479562 reaction equation
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[Cl:10][C:11]([Cl:15])([CH3:14])[CH:12]=O.[NH:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[N:17]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:16]1([CH:12]([NH:9][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=2)[C:11]([Cl:15])([Cl:10])[CH3:14])[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[N:17]1

Participants

5

Reactant 4

HCID 936NicotinamideHCID 6101p-Toluenesulfonic acidHCID 109754962,2-DichloropropanalHCID 178418385HCID 178418385, compound

Product 1

HCID 18770600N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]nicotinamide

Procedure

A suspension of nicotinamide, 2,2-dichloropropionaldehyde, benzotriazole, and p-toluenesulfonic acid was processed as described in Example 53A to provide the desired product.

Sources & evidence

ORD record
ord-f750b20da4414c5e98be51106d5df771
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Reaction notes

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