Trifluoroacetic acid → HCID 18768666, compound

HRID 480038Notes

Reaction equation

HRID 480038 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([O:24][CH3:25])=[O:23])=[CH:18][N:17]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([O:24][CH3:25])=[O:23])=[CH:18][N:17]=2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 17887112HCID 17887112, compound

Product 1

HCID 18768666HCID 18768666, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of example 30 is heated for 3 hours at 40° C. in a solution of CH2Cl2 containing 11 ml of CF3COOH. The solvent is evaporated off and the substance crystallised in acetone. The named product is obtained: M. P. 173-175° C.

Workup

  1. customThe solvent is evaporated off
  2. customthe substance crystallised in acetone
  3. customThe named product is obtained

Sources & evidence

ORD record
ord-d34379b090814baab78f5b9c52aafc7b
Source dataset
uspto-grants-2003_11
Patent number
US06649627B1

Reaction notes

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