Trifluoroacetic acid → HCID 18768675, compound

HRID 480039Notes

Reaction equation

HRID 480039 reaction equation
C(OC([NH:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([O:25][CH3:26])=[O:24])=[CH:19][N:18]=2)[CH2:12][CH2:11]1)=O)(C)(C)C.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28].ClCl>>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[NH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([O:25][CH3:26])=[O:24])=[CH:19][N:18]=2)[CH2:12][CH2:11]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 24526ChlorineHCID 17887098HCID 17887098, compound

Product 1

HCID 18768675HCID 18768675, compound

Conditions

Temperature
40 °C

Procedure

A solution containing 1.7 g (0.0046 mole) of the product of example 33, 15 ml of CF3COOH and 15 ml of CH2 Cl2 is heated at 40° C. for 3 hours. The solvent is evaporated off under vacuum, concentrated ammonia is added, and then an extraction with ethyl acetate carried out. The solvent is evaporated off and the named product obtained: M. P. 193-195° C.

Workup

  1. customThe solvent is evaporated off under vacuum, concentrated ammonia
  2. additionis added
  3. extractionan extraction with ethyl acetate
  4. customThe solvent is evaporated off
  5. customthe named product obtained

Sources & evidence

ORD record
ord-c09d25d9db654d42ad334327ecc3ee63
Source dataset
uspto-grants-2003_11
Patent number
US06649627B1

Reaction notes

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