反应详情

温度

-30 °C

To a stirred solution of diisopropylamine (84.5 ml, 600 mmol) in THF (anhydrous, 700 ml) cooled to −30° C. under nitrogen is added n-butyl lithium (2.5 M in hexane, 220 ml, 550 mmol) by a syringe. The misture is stirred for 30 min at −30° C. and then cooled to −78° C. HMPA (360 ml, 4 equivalents, 2 mol) is added by a syringe and a dolution of dimethyl cyclohexane-1,4-dicarboxylate (100 g, 500 mmol) in THF (anhydrous, 100 ml is added by a syringe subsequently. The mixture is stirred for an additional 40 min. Then 1-bromo-2-chloroethane (41.5 ml, 500 mmol) is added and the mixture stirred at −78° C. for an additional 20 min. The cold bath is removed and stirring is continued for 1 hr. The reaction mixture is cooled back to −78° and a mixture of HMPA (360 ml, 4 eq, 2 mol) in THF 600 ml) is added. By cannula, freshly prepared LDA (200 ml of n-butyl lithium, 2.5 M in hexane, 500 mmol is added to diisopropylamine (78 ml, 556 mmol) in THF (anhydrous, 700 ml)) is transferred into the reaction mixture at −78°. The reaction mixture is stirred at −78° for 1.33 hr followed by removal of the cooling bath and additional stirring for 5-6 hr. The mixture is quenched with saturated aqueous ammonium chloride (400 ml) and concentrated under reduced pressure at 35° to remove the THF. The residue is diluted with water (800 ml) and extracted with hexance (3×600 ml). The combined extracts are washed with saline (700 ml) and dried over sodium sulfate. Using a bath temperature of 35° the solvents are are removed under reduced pressure to give a residue. The residue is stirred with hexane (50 ml) at 20-25° for 0.5 hr. The resulting suspension is cooled to 0° for 2 hr and filtered to give the title compound.

1. temperaturecooled to −78° C
2. stirringThe mixture is stirred for an additional 40 min
3. stirringthe mixture stirred at −78° C. for an additional 20 min
4. customThe cold bath is removed
5. stirringstirring
6. waitis continued for 1 hr
7. temperatureThe reaction mixture is cooled back to −78°
8. additionis added
9. customis transferred into the reaction mixture at −78°
10. stirringThe reaction mixture is stirred at −78° for 1.33 hr
11. customfollowed by removal of the cooling bath
12. stirringadditional stirring for 5-6 hr
13. customThe mixture is quenched with saturated aqueous ammonium chloride (400 ml)
14. concentrationconcentrated under reduced pressure at 35°
15. customto remove the THF
16. additionThe residue is diluted with water (800 ml)
17. extractionextracted with hexance (3×600 ml)
18. washThe combined extracts are washed with saline (700 ml)
19. dry with materialdried over sodium sulfate
20. customtemperature of 35°
21. customare are removed under reduced pressure
22. customto give a residue
23. temperatureThe resulting suspension is cooled to 0° for 2 hr
24. filtrationfiltered