Potassium Carbonate → HCID 178450049, compound

HRID 480464Notes

Reaction equation

HRID 480464 reaction equation
[OH:1][C:2]([C:30]1[CH:31]=[C:32]2[C:37](=[CH:38][CH:39]=1)[CH:36]=[C:35](C=O)[CH:34]=[CH:33]2)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].S([CH2:52][N+:53]#[C-:54])(C1C=CC(C)=CC=1)(=O)=O.[C:55]([O-:58])([O-])=O.[K+].[K+]>CO.O>[NH:9]1[CH:10]=[C:6]([C:2]([C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[C:35]([C:55]4[O:58][CH:54]=[N:53][CH:52]=4)[CH:36]=3)[CH:31]=2)([OH:1])[CH:3]([CH3:4])[CH3:5])[N:7]=[CH:8]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 161915Tosylmethyl isocyanideHCID 18769144HCID 18769144, compound

Product 1

HCID 178450049HCID 178450049, compoundYield 111.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoaldehyde (2.0 g), tosylmethylisocyanide (800 mg) and K2CO3 (1.0 g) in methanol was refluxed for 2 h. The reaction mixture was diluted with water. The precipitate formed was collected and crystallized from THF-hexane to give the titled compound (1.39 g) as colorless powder.

Workup

  1. temperaturewas refluxed for 2 h
  2. customThe precipitate formed
  3. customwas collected
  4. customcrystallized from THF-hexane

Sources & evidence

ORD record
ord-71089d4bca2f466d9d9d13cf817a25da
Source dataset
uspto-grants-2003_11
Patent number
US06649643B1

Reaction notes

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