Hydrochloric Acid → HCID 69985920, compound

HRID 480592Notes

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:34][CH2:35][CH:36]4[CH2:38][CH2:37]4)=[C:17]([NH:20][C:21](=[O:33])[CH:22]=[CH:23][CH2:24][N:25]4[CH2:30][C@@H:29](C)[O:28][C:27](=[O:32])[CH2:26]4)[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8].[ClH:39].[CH2:40](Cl)Cl.[CH3:43][OH:44]>>[Cl:39][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:34][CH2:35][CH:36]4[CH2:38][CH2:37]4)=[C:17]([NH:20][C:21](=[O:33])[CH:22]=[CH:23][CH2:24][N:25]([CH2:26][C:27]([O:28][CH3:29])=[O:32])[CH2:30][C@H:43]([OH:44])[CH3:40])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 21226129Dichloromethane methanol

HCID 66616904HCID 66616904, compound

Product 1

HCID 69985920HCID 69985920, compound

Procedure

Obtained by treating a methanolic solution of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-((R)-6-methyl-2-oxomorpholin-4-yl)-1-oxo-2-buten-1-yl]amino}-7-cyclopropylmethoxyquinazoline with ethereal hydrochloric acid at room temperature. Rf value: 0.37 (silica gel, methylene chloride/methanol=20:1); mass spectrum (ESI−): m/z=570, 572 [M−H]−.

Workup

customObtained

Sources & evidence

ORD record: ord-3e72cd31c9e64d6aad0111d5275c1a91
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06653305B2

Reaction notes

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