HCID 69943756, compound → HCID 69944557, compound

HRID 480651Notes

Reaction equation

HRID 480651 reaction equation
[NH2:1][S:2]([C:5]1[C:10]([OH:11])=[C:9]([N+:12]([O-])=O)[N:8]=[CH:7][C:6]=1[Cl:15])(=[O:4])=[O:3]>C(OCC)(=O)C.[Pd]>[NH2:1][S:2]([C:5]1[C:10]([OH:11])=[C:9]([NH2:12])[N:8]=[CH:7][C:6]=1[Cl:15])(=[O:3])=[O:4]

Participants

4

Reactant 1

HCID 69943756HCID 69943756, compound

Product 1

HCID 69944557HCID 69944557, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(aminosulfonyl) 3-chloro 5-hydroxy 6-nitro pyridine (4.36 mmol) in ethyl acetate, was added 10% Pd/C (500 mg). The mixture was flushed with argon, and then stirred under a hydrogen atmosphere at balloon pressure for 4 hours at room temperature. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated to give the desired product.

Workup

  1. customThe mixture was flushed with argon
  2. filtrationThe mixture was filtered through celite
  3. washthe celite was washed with methanol
  4. customThe solvent was evaporated

Sources & evidence

ORD record
ord-40f16b72b9f945d9b3ffd2d4cd3fcf41
Source dataset
uspto-grants-2003_11
Patent number
US06653310B2

Reaction notes

Loading…