反应详情

温度

80 °C

Allyl 3-hydroxyphenylacetate (7.63 g, 50.10 mmol), potassium carbonate (13.85 g, 100.3 mmol), and tert-butyl 2-bromoisobutyrate (30.37 g, 100.3 mmol) were dissolved in dimethylformamide (9 mL), and the mixture was stirred for 13 hours at 80° C. The reaction mixture was added to water, and the resultant mixture was extracted with diethyl ether, followed by washing sequentially with water and saturated brine. The mixture was subjected to drying over magnesium sulfate, concentration under reduced pressure, and purification by silica gel column chromatography (n-hexane/ethyl acetate=20/1), whereby the target compound was obtained (3.55 g, 10.62 mmol, 21.2%).

1. extractionthe resultant mixture was extracted with diethyl ether
2. washby washing sequentially with water and saturated brine
3. dry with materialto drying over magnesium sulfate, concentration under reduced pressure, and purification by silica gel column chromatography (n-hexane/ethyl acetate=20/1), whereby the target compound
4. customwas obtained (3.55 g, 10.62 mmol, 21.2%)