Hydrochloric Acid → HCID 10976084, compound

HRID 480975Notes

Reaction equation

HRID 480975 reaction equation
[OH:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[C:5]([O:10]C(=O)C)=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+].O.Cl>CO>[OH:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[C:5]([OH:10])=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962Water2×HCID 11430Potassium CarbonateHCID 9794488HCID 9794488, compound

Product 1

HCID 10976084HCID 10976084, compoundYield 86.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The phenylethanone of Step 2 (500 mg) was dissolved in MeOH (20 mL), and potassium carbonate (1 eq.) was added followed by water (1 mL). The mixture was stirred at room temperature for 1 h, and then was poured into water. The solution was acidified with HCl and a precipitate was formed. The precipitate was collected and air dried to give about 350 mg of 1-(2,5-dihydroxy-3,4-dimethyl-phenyl)-ethanone.

Workup

  1. customa precipitate was formed
  2. customThe precipitate was collected
  3. customair dried

Sources & evidence

ORD record
ord-a18422a6b4284bcd9011a57e13395db7
Source dataset
uspto-grants-2003_11
Patent number
US06653346B1

Reaction notes

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