反应详情

To a solution of 6-hydroxy methyl-naphthalen-2-ol (16) (1 equi.) and benzyl bromide (2) (1 equi.) in DMF (3 mL/mmole), cesium carbonate (1.25 equi.) was added at room temperature. The reaction mixture was stirred at that temperature for 24 h, quenched with water, extracted with ethyl acetate:hexane(1:1), washed with brine, dried over MgSO4, and concentrated in vacuo. Purification by chromatography on silica gel (20% THF/hexanes) and recrystallization from EtOAc-Hexane (1:2) afforded (6-benzyloxy-naphthalen-2-yl)-methanol (17) a white solid (88%).

1. customquenched with water
2. extractionextracted with ethyl acetate:hexane(1:1)
3. washwashed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo
6. customPurification by chromatography
7. customon silica gel (20% THF/hexanes) and recrystallization from EtOAc-Hexane (1:2)